Picking pyknons out of the human genome. [Cell. 2006]

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1: Cell. 2006 Jun 2;125(5):836-8. Links

Picking pyknons out of the human genome.

Meynert A, Birney E.

European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom.

In a recent paper in PNAS, Rigoutsos et al. (2006) describe a nonrandom pattern of repeated elements, called pyknons, which are found more frequently in the 3' untranslated regions of genes than in other regions of the human genome. Although it is unclear how pyknons might have arisen, it is possible that they may be involved in a new form of gene regulation.

PMID: 16751093 [PubMed - indexed for MEDLINE]

Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes. [Proc Natl Acad Sci U S A. 2006]
Identification of candidate regulatory sequences in mammalian 3' UTRs by statistical analysis of oligonucleotide distributions. [BMC Bioinformatics. 2007]
The regulatory code for transcriptional response diversity and its relation to genome structural properties in A. thaliana. [PLoS Genet. 2007]
Abundance of microRNA target motifs in the 3'-UTRs of 20527 human genes. [FEBS Lett. 2007]
Transcriptional regulatory elements in the human genome. [Annu Rev Genomics Hum Genet. 2006]
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Picking pyknons out of the human genome.

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