Leuk Res. 2007 Feb;31(2):195-202. Epub 2006 Jun 5.

In vitro generation of tumor specific T cells that recognize a shared antigen of AML: molecular characterization of TCR genes.

Coppage M, Belanger T, Zauderer M, Sahasrabudhe D.

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University of Rochester Department of Pathology and Laboratory Medicine, 601 Elmwood Avenue, Rochester, NY 14642, United States. Sara.Rollinson@manchester.ac.uk

Abstract

The identification of immunologically relevant tumor antigens is hampered by the difficulty of generating tumor-specific cytotoxic T cells (CTL). We present data demonstrating in vitro induction of autologous acute myelogenous leukemia (AML)-specific CTL. The specific T cell receptor has been identified and cloned. The CTL demonstrated specific lysis to autologous tumor blasts, but not to autologous BLCL or the NK-sensitive target K562. The clone secreted GM-CSF, TNFa, and IFNg when stimulated with AML blasts from 3 of 11 patients or cell lines tested, but not with K562 or autologous B-LCL. These three AML samples share a single HLA Class I antigen, HLA-A24. The T cell receptor genes identified by molecular methods are Vbeta7.9-J2.3-Cbeta2 and Valpha17-J49-Calpha.

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Leuk Res. 2007 Feb;31(2):127-8.

PMID:: 16750565; [PubMed - indexed for MEDLINE]

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In vitro generation of tumor specific T cells that recognize a shared antigen of AML: molecular characterization of TCR genes.

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