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Trends Microbiol. 2006 Jul;14(7):287-9. Epub 2006 Jun 5.

A genetic basis for human susceptibility to West Nile virus.

Author information

  • 1Department of Medicine, Washington University School of Medicine, Box 8051, 660 S. Euclid Avenue, St. Louis, MO 63110, USA. diamond@borcim.wustl.edu

Abstract

West Nile virus (WNV) infects thousands of humans annually and causes a spectrum of disease ranging from an acute febrile illness to lethal encephalitis. A new study suggests a link between CCR5Delta32 (a common mutant allele of the chemokine and HIV receptor CCR5) and fatal WNV infection. The study highlights a possible risk in targeting this receptor for the prevention and/or treatment of infectious diseases.

PMID:
16750369
[PubMed - indexed for MEDLINE]
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