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G Ital Cardiol (Rome). 2006 Apr;7(4 Suppl 1):13S-20S.

[Therapeutic strategies to improve the outcome of patients with diabetes mellitus and acute coronary syndrome].

[Article in Italian]

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  • 1Struttura Complessa di Cardiologia, Ospedale R Silvestrini, Perugia.


Diabetes mellitus is a major risk factor for cardiovascular morbidity and mortality. The burden of cardiovascular disease associated with this condition will increase dramatically, because the prevalence of diabetes is estimated to double over the next few decades. Diabetic patients show a poor short- and long-term outcome in the setting of ST-segment-elevation and non-ST-segment-elevation acute coronary syndromes, with a 2-fold acute mortality compared with non-diabetics. Although no specifically designed clinical trials in diabetics with acute coronary syndromes are available at present, many data suggest that an aggressive approach, such as early mechanical revascularization with the use of platelet glycoprotein IIb/IIIa inhibitors and of drug-eluting stents, associated with a strict glycemic control during hospital stay, can improve the prognosis of these patients. Nonetheless, these strategies appear to be underused in current practice, representing a missed opportunity for improving outcomes in this high-risk population.

[PubMed - indexed for MEDLINE]
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