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Mol Syst Biol. 2006;2:2006.0017. Epub 2006 May 2.

Core transcriptional regulatory circuitry in human hepatocytes.

Author information

  • 1Young Laboratory, Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

Abstract

We mapped the transcriptional regulatory circuitry for six master regulators in human hepatocytes using chromatin immunoprecipitation and high-resolution promoter microarrays. The results show that these regulators form a highly interconnected core circuitry, and reveal the local regulatory network motifs created by regulator-gene interactions. Autoregulation was a prominent theme among these regulators. We found that hepatocyte master regulators tend to bind promoter regions combinatorially and that the number of transcription factors bound to a promoter corresponds with observed gene expression. Our studies reveal portions of the core circuitry of human hepatocytes.

PMID:
16738562
[PubMed - indexed for MEDLINE]
PMCID:
PMC1681491
Free PMC Article

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