Lancet. 1991 May 18;337(8751):1190.

Chromosome translocation and c-MYC activation by Epstein-Barr virus and Euphorbia tirucalli in B lymphocytes.

Aya T, Kinoshita T, Imai S, Koizumi S, Mizuno F, Osato T, Satoh C, Oikawa T, Kuzumaki N, Ohigashi H, et al.

Source

Department of Virology, Hokkaido University School of Medicine, Sapporo, Japan.

Abstract

Dual exposure to Epstein-Barr virus and purified 4-deoxyphorbol ester derived from the plant Euphorbia tirucalli induced a high frequency of chromosomal rearrangements in human B lymphocytes in vitro. Rearrangements most commonly affected chromosome 8, the chromosome most often showing structural changes in Burkitt's lymphoma (BL) cells. E tirucalli is indigenous in parts of Africa where BL is endemic and may be an important risk factor for the disease.

Comment in

Lancet. 1992 Feb 15;339(8790):434.

PMID:: 1673740; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

EBSCO

Medical

Lymphoma - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

African Burkitt's lymphoma: a plant, Euphorbia tirucalli, reduces Epstein-Barr virus-specific cellular immunity. [Anticancer Res. 1994]
African Burkitt's lymphoma: a plant, Euphorbia tirucalli, reduces Epstein-Barr virus-specific cellular immunity.
Imai S, Sugiura M, Mizuno F, Ohigashi H, Koshimizu K, Chiba S, Osato T. Anticancer Res. 1994 May-Jun; 14(3A):933-6.
Review Biology of the lymphomas: cytogenetics, molecular biology, and virology. [Curr Opin Oncol. 1991]
Review Biology of the lymphomas: cytogenetics, molecular biology, and virology.
Ambinder RF, Griffin CA. Curr Opin Oncol. 1991 Oct; 3(5):806-12.
African Burkitt's lymphoma and an Epstein-Barr virus-enhancing plant Euphorbia tirucalli. [Lancet. 1987]
African Burkitt's lymphoma and an Epstein-Barr virus-enhancing plant Euphorbia tirucalli.
Osato T, Mizuno F, Imai S, Aya T, Koizumi S, Kinoshita T, Tokuda H, Ito Y, Hirai N, Hirota M. Lancet. 1987 May 30; 1(8544):1257-8.
Suppression of the malignant phenotype in somatic cell hybrids between Burkitt's lymphoma cells and Epstein-Barr virus-immortalized lymphoblastoid cells despite deregulated c-myc expression. [Cancer Res. 1990]
Suppression of the malignant phenotype in somatic cell hybrids between Burkitt's lymphoma cells and Epstein-Barr virus-immortalized lymphoblastoid cells despite deregulated c-myc expression.
Wolf J, Pawlita M, Bullerdiek J, zur Hausen H. Cancer Res. 1990 May 15; 50(10):3095-100.
Review The etiology of Burkitt's lymphoma and the history of the shaken dogmas. [Blood Cells. 1993]
Review The etiology of Burkitt's lymphoma and the history of the shaken dogmas.
de Thé G. Blood Cells. 1993; 19(3):667-73; discussion 674-5.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Burkitt's lymphoma in Africa, a review of the epidemiology and etiology. [Afr Health Sci. 2007]
Review Burkitt's lymphoma in Africa, a review of the epidemiology and etiology.
Orem J, Mbidde EK, Lambert B, de Sanjose S, Weiderpass E. Afr Health Sci. 2007 Sep; 7(3):166-75.
Are plant factors a missing link in the evolution of endemic Burkitt's lymphoma? [Br J Cancer. 1993]
Are plant factors a missing link in the evolution of endemic Burkitt's lymphoma?
van den Bosch C, Griffin BE, Kazembe P, Dziweni C, Kadzamira L. Br J Cancer. 1993 Dec; 68(6):1232-5.
Tumour promoter activity in Malaysian Euphorbiaceae. [Br J Cancer. 1995]
Tumour promoter activity in Malaysian Euphorbiaceae.
Norhanom AW, Yadav M. Br J Cancer. 1995 Apr; 71(4):776-9.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Chromosome translocation and c-MYC activation by Epstein-Barr virus and Euphorbi...
Chromosome translocation and c-MYC activation by Epstein-Barr virus and Euphorbia tirucalli in B lymphocytes.
Lancet. 1991 May 18 ;337(8751):1190.

PubMed
Personality in its natural habitat: manifestations and implicit folk theories of...
Personality in its natural habitat: manifestations and implicit folk theories of personality in daily life.
J Pers Soc Psychol. 2006 May ;90(5):862-77.

PubMed
Randomised study of antiepileptic drug withdrawal in patients in remission. Medi...
Randomised study of antiepileptic drug withdrawal in patients in remission. Medical Research Council Antiepileptic Drug Withdrawal Study Group.
Lancet. 1991 May 18 ;337(8751):1175-80.

PubMed
Acute-phase serum amyloid A: an inflammatory adipokine and potential link betwee...
Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications.
PLoS Med. 2006 Jun ;3(6):e287.

PubMed
Rational prescribing in primary care (RaPP): economic evaluation of an intervent...
Rational prescribing in primary care (RaPP): economic evaluation of an intervention to improve professional practice.
PLoS Med. 2006 Jun ;3(6):e216.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: