Hum Exp Toxicol. 1991 Jan;10(1):59-62.

Life-threatening ventricular arrhythmia (torsades de pointes) after haloperidol overdose.

Source

Guy's Hospital, London, UK.

Abstract

A 48-year-old woman developed QT prolongation and episodes of life-threatening ventricular tachycardia (torsades de pointes) after intentional overdose of haloperidol and orphenadrine. The arrhythmia did not respond to conventional anti-arrhythmic therapy but was suppressed by atrial overdrive pacing. A literature review identified haloperidol as the most likely cause of the torsades de pointes.

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