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Parkinsonism Relat Disord. 2007 Apr;13(3):182-4. Epub 2006 May 30.

Monomelic parkinsonian tremor caused by contralateral substantia nigra stroke.

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  • 1Department of Neurology, University of Iowa College of Medicine, Iowa, USA.


Patients with Parkinson's disease have been frequently classified by their most prominent symptoms into tremor-predominant and akinetic/rigid variants. A few pathological studies have suggested that these different phenotypes represent topographical differences in nigral pathology. A patient is described in whom a medial substantia nigra stroke led to contralateral lower extremity parkinsonian tremor, providing a clinical-pathological correlation of this tremor, indicating a somatotopic organization of the substantia nigra and supporting the central generator hypothesis of parkinsonian tremor.

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