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Biochim Biophys Acta. 2006 May-Jun;1763(5-6):542-8. Epub 2006 Apr 20.

Structure and dynamics of the mitochondrial inner membrane cristae.

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  • 1Resource for Visualization of Biological Complexity, Wadsworth Center, Empire State Plaza, Albany, NY 12201-0509, USA. carmen@wadsworth.org

Abstract

Three-dimensional images of mitochondria provided by electron tomography reveal that the micro-compartments (cristae) defined by the inner membrane are connected to the periphery of this membrane by narrow tubular junctions, which likely restrict diffusion. The tomograms also strongly suggest that inner membrane topology represents a balance between membrane fusion and fission processes. The hypothesis being developed is that inner membrane topology is a regulated property of mitochondria. This review summarizes the evidence about how inner membrane shape influences mitochondrial function and, conversely, what is known about the factors that determine this membrane's topology.

PMID:
16730811
[PubMed - indexed for MEDLINE]
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