Format

Send to:

Choose Destination
See comment in PubMed Commons below
Otolaryngol Head Neck Surg. 2006 Jun;134(6):893-900.

A hormonal association between estrogen metabolism and proliferative thyroid disease.

Author information

  • 1Department of Otolaryngology-Head and Neck Surgery, New York Medical College, New York, New York 10003, USA. echan@nyee.edu

Abstract

OBJECTIVE:

To illustrate a relationship between proliferative thyroid disease and estrogen metabolism through the analysis of urinary estrogen metabolites.

STUDY DESIGN AND SETTING:

Case-control study of 49 subjects with proliferative thyroid disorders and matching them to 49 controls. Urinary estrogen metabolite ratios were obtained, measuring 2-hydroxyestrone, an anti-proliferative metabolite, to 16alpha-hydroxyestrone, a proliferative metabolite. The patients were stratified into low (0 to 1.00), medium (1.01 to 2.00), or high (>2.00) groups according to their estrogen metabolite ratio.

RESULTS:

Fifty-one percent (25 of 49) of the cases had a low 2/16 ratio compared to 31% (15 of 49) in the control group while 20% (10 of 49) of the control group had a high 2/16 ratio as compared to 8% (4 of 49) in the case group (P value < 0.05).

CONCLUSIONS:

Increased 16alpha-hydroxyestrone activity compared to 2-hydroxyestrone activity appears to be associated with proliferative thyroid disease.

SIGNIFICANCE:

Further study of estrogen metabolites in relation to proliferative thyroid disease is warranted and may lead to implications for new treatment modalities for proliferative thyroid disease.

EBM RATING:

B-3b.

PMID:
16730526
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk