Am J Gastroenterol. 1991 Apr;86(4):512-4.

Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome.

McQuillen DP, Schroy PC, Hesketh PJ, Sugar AM.

Source

Maxwell Finland Laboratory for Infectious Diseases, Boston City Hospital, Massachusetts.

Abstract

Described is the case of a 73-yr-old woman with metastatic pancreatic islet carcinoma that manifested initially as Zollinger-Ellison syndrome followed by onset of endogenous Cushing's syndrome, who developed Pneumocystis carinii pneumonia while on therapy with a long-acting somatostatin analog. Although P. carinii pneumonia has been observed in patients with Cushing's syndrome associated with other conditions, this is the first reported case in a patient with Zollinger-Ellison syndrome. Heightened awareness of the possibility of opportunistic infections in patients receiving somatostatin therapy for Cushing's syndrome of any cause, particularly Zollinger-Ellison syndrome, may be warranted.

PMID:: 1672788; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

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Case Reports

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Somatostatin

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Related citations in PubMed

[Islet cell carcinoma associated with concurrent Zollinger-Ellison syndrome and Cushing's syndrome]. [Gan No Rinsho. 1987]
[Islet cell carcinoma associated with concurrent Zollinger-Ellison syndrome and Cushing's syndrome].
Yoshida Y, Tsuji S, Mori M, Satoh M, Kamijo K, Yabana T, Yachi A, Imamura M. Gan No Rinsho. 1987 Oct; 33(12):1446-52.
Review Pancreatic islet cell carcinoma presenting with concurrent Cushing's and Zollinger-Ellison syndromes: case series and literature review. [Eur J Gastroenterol Hepatol. 2...]
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Said R, O'Reilly EM, Blumgart L, Shia J, Abou-Alfa GK. Eur J Gastroenterol Hepatol. 2010 Feb; 22(2):246-52.
Cushing's syndrome in patients with the Zollinger-Ellison syndrome. [N Engl J Med. 1986]
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Maton PN, Gardner JD, Jensen RT. N Engl J Med. 1986 Jul 3; 315(1):1-5.
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Ruszniewski P, Girard F, Benamouzig R, Mignon M, Bonfils S. Gut. 1988 Jun; 29(6):838-42.
Review Concurrent Cushing's and Zollinger-Ellison syndromes in a patient with islet cell carcinoma. Case report and review of the literature. [Am J Med. 1984]
Review Concurrent Cushing's and Zollinger-Ellison syndromes in a patient with islet cell carcinoma. Case report and review of the literature.
Lyons DF, Eisen BR, Clark MR, Pysher TJ, Welsh JD, Kem DC. Am J Med. 1984 Apr; 76(4):729-33.

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