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Nat Rev Cancer. 2006 Jun;6(6):437-48.

Evolving concepts in the pathogenesis of hairy-cell leukaemia.

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  • 1Institute of Haematology, University of Perugia, Italy. enrico.tiacci@uni-essen.de

Abstract

Hairy-cell leukaemia (HCL) has long been recognized as distinct from other chronic B-cell malignancies, but several questions remain unanswered. What is the HCL cell of origin? Why does HCL lack the hallmarks of most mature B-cell tumours (for example, chromosomal translocations and consistent lymph node involvement) and show unique features like 'hairy' morphology and bone-marrow fibrosis? Gene-expression profiling and other studies have recently provided new insights into HCL biology and have the potential to affect clinical practice.

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