Nat Rev Cancer. 2006 Jun;6(6):437-48.

Evolving concepts in the pathogenesis of hairy-cell leukaemia.

Source

Institute of Haematology, University of Perugia, Italy. enrico.tiacci@uni-essen.de

Abstract

Hairy-cell leukaemia (HCL) has long been recognized as distinct from other chronic B-cell malignancies, but several questions remain unanswered. What is the HCL cell of origin? Why does HCL lack the hallmarks of most mature B-cell tumours (for example, chromosomal translocations and consistent lymph node involvement) and show unique features like 'hairy' morphology and bone-marrow fibrosis? Gene-expression profiling and other studies have recently provided new insights into HCL biology and have the potential to affect clinical practice.

PMID:: 16723990; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature. [Blood. 2004]
Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature.
Vanhentenrijk V, De Wolf-Peeters C, Wlodarska I, Belgian Programme of Interuniversity Poles of Attraction. Blood. 2004 Jul 1; 104(1):250-5. Epub 2004 Mar 11.
Gene expression profiling of hairy cell leukemia reveals a phenotype related to memory B cells with altered expression of chemokine and adhesion receptors. [J Exp Med. 2004]
Gene expression profiling of hairy cell leukemia reveals a phenotype related to memory B cells with altered expression of chemokine and adhesion receptors.
Basso K, Liso A, Tiacci E, Benedetti R, Pulsoni A, Foa R, Di Raimondo F, Ambrosetti A, Califano A, Klein U, et al. J Exp Med. 2004 Jan 5; 199(1):59-68.
Review The variant form of hairy-cell leukaemia. [Best Pract Res Clin Haematol. ...]
Review The variant form of hairy-cell leukaemia.
Matutes E, Wotherspoon A, Catovsky D. Best Pract Res Clin Haematol. 2003 Mar; 16(1):41-56.
Absence of surface CD27 distinguishes hairy cell leukemia from other leukemic B-cell malignancies. [Haematologica. 2005]
Absence of surface CD27 distinguishes hairy cell leukemia from other leukemic B-cell malignancies.
Forconi F, Raspadori D, Lenoci M, Lauria F. Haematologica. 2005 Feb; 90(2):266-8.
Review The biology of hairy cells. [Best Pract Res Clin Haematol. ...]
Review The biology of hairy cells.
Zuzel M, Cawley JC. Best Pract Res Clin Haematol. 2003 Mar; 16(1):1-13.

See reviews... See all...

Cited by 1 PubMed Central article

Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia. [Haematologica. 2013]
Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia.
Tiacci E, Schiavoni G, Martelli MP, Boveri E, Pacini R, Tabarrini A, Zibellini S, Santi A, Pettirossi V, Fortini E, et al. Haematologica. 2013 Apr; 98(4):635-9. Epub 2013 Jan 24.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
MedGen
Related information in MedGen
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Evolving concepts in the pathogenesis of hairy-cell leukaemia.
Evolving concepts in the pathogenesis of hairy-cell leukaemia.
Nat Rev Cancer. 2006 Jun ;6(6):437-48.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: