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Nat Rev Mol Cell Biol. 2006 Jul;7(7):540-6. Epub 2006 May 17.

Chromatin in pluripotent embryonic stem cells and differentiation.

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  • 1National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.


Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.

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