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J Neuropsychiatry Clin Neurosci. 2006 Spring;18(2):178-85.

Donepezil effects on cerebral blood flow in older adults with mild cognitive deficits.

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  • 1Department of Radiology, The Roy J. and Lucille A. Carver College of Medicine, 500 Newton Rd., Iowa City, IA 52242-1000, USA.


Cerebral blood flow (CBF) was assessed during a verbal recall task using [(15)O]water positron emission tomography (PET) in older adults with mild cognitive deficits participating in a placebo-controlled donepezil trial. The placebo group demonstrated reduced CBF in the left frontal and temporal regions over the 6-month period, while those receiving donepezil did not. The placebo group's performance did not change on a list-learning task, while the donepezil group's performance improved, despite having had lower performance at intake. These findings suggest that donepezil treatment may be associated with a relative maintenance of CBF and improved list-learning.

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