Pharmacotherapy. 2006 May;26(5):709-12.

Lepirudin anticoagulation for heparin-induced thrombocytopenia after cardiac surgery in a pediatric patient.

Knoderer CA, Knoderer HM, Turrentine MW, Kumar M.

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Department of Pharmacy, Clarian Health Partners, Riley Hospital for Children, Indianapolis, IN 46202, USA. cknoderer@clarian.org

Abstract

A 21-month-old boy received anticoagulation with lepirudin for heparin-induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the successful administration of lepirudin in this setting. To our knowledge, this is the first published report of lepirudin administered to treat HIT in a child after cardiac surgery and ECMO. Although guidelines exist that suggest the potential administration of lepirudin as treatment for children with HIT, further studies are needed to determine the safest yet most effective dosage for this population.

PMID:: 16718945; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

The Pharmacotherapy of Heparin-Induced Thrombocytopenia (HIT) : A Review of Contemporary Therapeutic Challenges in Clinical Practice. [Malays J Med Sci. 2008]
The Pharmacotherapy of Heparin-Induced Thrombocytopenia (HIT) : A Review of Contemporary Therapeutic Challenges in Clinical Practice.
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