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Nat Immunol. 2006 Jun;7(6):539-41.

Origins of the T(H)1-T(H)2 model: a personal perspective.

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  • 1Dynavax Technologies, Berkeley, California 94710, USA.


Robert L. Coffman recounts how his work on immunoglobulin E regulation along with data from Tim Mosmann on the functional heterogeneity of T cell clones led to the T helper type 1-T helper type 2 hypothesis.

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