Format

Send to:

Choose Destination
See comment in PubMed Commons below
Immunity. 2006 May;24(5):495-9.

Aging of the immune system: how much can the adaptive immune system adapt?

Author information

  • 1Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA. wengn@mail.nih.gov

Abstract

The competency of the adaptive immune function decreases with age, primarily because of the decline in production of naive lymphocytes in the bone marrow and thymus as well as the expansion of incompetent memory lymphocytes. Here I discuss the recent progress on age-associated changes in lymphocytes and their effect on the adaptive immune system.

Comment in

PMID:
16713964
[PubMed - indexed for MEDLINE]
PMCID:
PMC2266981
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk