Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Hand Surg Am. 2006 May-Jun;31(5):693-704.

Tendon tissue engineering and gene transfer: the future of surgical treatment.

Author information

  • 1Department of Orthopaedic Surgery, Orthopaedic Research Laboratories, University of Virginia Hand Center, Charlottesville 22908, USA.

Abstract

Technologic improvements in the field of tissue engineering are leading to new potential developments in the currently used approaches to treat tendon injuries including difficult clinical scenarios such as zone II flexor tendon injuries of the hand and the mutilated hand with extensive tendon defects. A combination of mesenchymal (adult stem) cells, growth factors, and bioresorbable polymers can provide a solution for the treatment of difficult tendon injuries. Extensive research is needed to show that the extracellular matrix produced in response to the cell/growth factor/polymer composites in vivo is effective and functional as a regenerate tissue. Further exciting advances are foreseen in cell-based genetic engineering with the transfer of DNA to the site of tendon lacerations. These treatment modalities require improved safety precautions to reduce the risks and enhance the benefits of gene therapy.

PMID:
16713828
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk