Trends Parasitol. 2006 Jul;22(7):296-300. Epub 2006 May 19.

The IPTi Consortium: research for policy and action.

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Department of Infectious Diseases, London School of Hygiene & Tropical Medicine, University of London, Keppel Street, London WC1E 7HT, UK. DMSchellenberg@aol.com

Abstract

The results of a randomized controlled trial in Tanzania suggest that intermittent preventive treatment in infants (IPTi), delivered through the Expanded Program on Immunization, might be a useful approach to controlling malaria in countries where it is endemic. An international consortium of research collaborations, involving the World Health Organization and United Nation's Children's Fund, is now evaluating IPTi in a range of different settings to generate robust and compelling evidence to guide policy. This review summarizes the available information on IPTi and presents the consortium's approach to determining whether IPTi might be a valuable additional strategy in programs to control malaria.

PMID:: 16713739; [PubMed - indexed for MEDLINE]

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Antimalarials

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The acceptability of intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in southern Tanzania. [Malar J. 2008]
The acceptability of intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in southern Tanzania.
Pool R, Mushi A, Schellenberg JA, Mrisho M, Alonso P, Montgomery C, Tanner M, Mshinda H, Schellenberg D. Malar J. 2008 Oct 21; 7:213. Epub 2008 Oct 21.
Community response to intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in five African settings. [Malar J. 2009]
Community response to intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in five African settings.
Gysels M, Pell C, Mathanga DP, Adongo P, Odhiambo F, Gosling R, Akweongo P, Mwangi R, Okello G, Mangesho P, et al. Malar J. 2009 Aug 10; 8:191. Epub 2009 Aug 10.
Varying efficacy of intermittent preventive treatment for malaria in infants in two similar trials: public health implications. [Malar J. 2007]
Varying efficacy of intermittent preventive treatment for malaria in infants in two similar trials: public health implications.
Menendez C, Schellenberg D, Macete E, Aide P, Kahigwa E, Sanz S, Aponte JJ, Sacarlal J, Mshinda H, Tanner M, et al. Malar J. 2007 Sep 26; 6:132. Epub 2007 Sep 26.
Review Intermittent preventive treatment of malaria in infants: how does it work and where will it work? [Trop Med Int Health. 2009]
Review Intermittent preventive treatment of malaria in infants: how does it work and where will it work?
Gosling RD, Carneiro I, Chandramohan D. Trop Med Int Health. 2009 Sep; 14(9):1003-10. Epub 2009 Jun 22.
Review Intermittent preventive therapy for malaria: progress and future directions. [Curr Opin Infect Dis. 2007]
Review Intermittent preventive therapy for malaria: progress and future directions.
Grobusch MP, Egan A, Gosling RD, Newman RD. Curr Opin Infect Dis. 2007 Dec; 20(6):613-20.

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Cited by 17 PubMed Central articles

Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial. [PLoS Med. 2012]
Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial.
Senn N, Rarau P, Stanisic DI, Robinson L, Barnadas C, Manong D, Salib M, Iga J, Tarongka N, Ley S, et al. PLoS Med. 2012 Mar; 9(3):e1001195. Epub 2012 Mar 27.
Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice. [Malar J. 2011]
Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice.
Dow GS, Milner E, Bathurst I, Bhonsle J, Caridha D, Gardner S, Gerena L, Kozar M, Lanteri C, Mannila A, et al. Malar J. 2011 Jun 6; 10:150. Epub 2011 Jun 6.
Evaluating the effectiveness of IPTi on malaria using routine health information from sentinel health centres in southern Tanzania. [Malar J. 2011]
Evaluating the effectiveness of IPTi on malaria using routine health information from sentinel health centres in southern Tanzania.
Willey BA, Armstrong Schellenberg JR, Maokola W, Shirima K, Chemba M, Mshinda H, Alonso P, Tanner M, Schellenberg D. Malar J. 2011 Feb 14; 10(1):41. Epub 2011 Feb 14.

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