Abstract
In this issue of Molecular Cell, Reef et al. (2006) describe a shortened unstable form of the ARF tumor suppressor protein that localizes within mitochondria, where it reduces membrane potential and triggers autophagy. Could this account for the Mdm2- and p53-independent tumor suppressive effects of ARF?
MeSH terms
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Animals
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Autophagy / physiology*
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Cyclin-Dependent Kinase Inhibitor p16
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Genes, p53
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Humans
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Membrane Potentials
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Mice
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Mitochondria / metabolism
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Proto-Oncogene Proteins c-mdm2 / genetics
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Proto-Oncogene Proteins c-mdm2 / metabolism
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Tumor Suppressor Protein p14ARF / chemistry
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Tumor Suppressor Protein p14ARF / genetics
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Tumor Suppressor Protein p14ARF / metabolism*
Substances
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Cdkn2a protein, mouse
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Cyclin-Dependent Kinase Inhibitor p16
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Tumor Suppressor Protein p14ARF
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Mdm2 protein, mouse
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Proto-Oncogene Proteins c-mdm2