Autophagy by ARF: a short story

Mol Cell. 2006 May 19;22(4):436-7. doi: 10.1016/j.molcel.2006.05.005.

Abstract

In this issue of Molecular Cell, Reef et al. (2006) describe a shortened unstable form of the ARF tumor suppressor protein that localizes within mitochondria, where it reduces membrane potential and triggers autophagy. Could this account for the Mdm2- and p53-independent tumor suppressive effects of ARF?

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Autophagy / physiology*
  • Cyclin-Dependent Kinase Inhibitor p16
  • Genes, p53
  • Humans
  • Membrane Potentials
  • Mice
  • Mitochondria / metabolism
  • Proto-Oncogene Proteins c-mdm2 / genetics
  • Proto-Oncogene Proteins c-mdm2 / metabolism
  • Tumor Suppressor Protein p14ARF / chemistry
  • Tumor Suppressor Protein p14ARF / genetics
  • Tumor Suppressor Protein p14ARF / metabolism*

Substances

  • Cdkn2a protein, mouse
  • Cyclin-Dependent Kinase Inhibitor p16
  • Tumor Suppressor Protein p14ARF
  • Mdm2 protein, mouse
  • Proto-Oncogene Proteins c-mdm2