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J Am Acad Dermatol. 2006 Jun;54(6):987.e1-14. Epub 2006 Apr 19.

Development and reliability testing of a standardized questionnaire to assess psoriasis phenotype.

Author information

  • 1Department of Dermatology, George Washington University, Washington, DC 20037, USA. aehrlich@mfa.gwu.edu

Abstract

BACKGROUND:

Psoriasis genetics researchers have utilized separate and widely differing survey instruments to capture clinical data to be utilized in genotype-phenotype studies, which make comparison and collaboration studies among these researchers difficult.

OBJECTIVE:

The purpose of this study was to develop and validate a clinical survey instrument to facilitate future collaborative genotype-phenotype studies among psoriasis genetics researchers.

METHODS:

The Delphi method was employed to obtain international consensus on components of the novel survey instrument. The survey was pretested for acceptability purposes, and then formally tested for reliability using 3 independent raters interviewing 48 subjects with psoriasis.

RESULTS:

Data showed high or moderately high agreement for questions relating to place of birth (85% to 100% in agreement), family origin (kappa = 0.48 -1.0), psoriasis history (kappa = 0.66-1.0), patient medical history (kappa = 0.76-1.0), distribution of lesions (kappa = 0.73-1.0), precipitating factors (kappa = 0.79-1.0), joint involvement (kappa = 0.74-.91), and treatment history, including use of oral retinoids, methotrexate, and etanercept (kappa = 0.73-1.0). Other parameters had lower degrees of agreement.

LIMITATIONS:

The time involved and the need for the rater to be a clinician with knowledge of psoriasis may preclude widespread use of this survey instrument.

CONCLUSION:

We developed a novel, reliable survey instrument that can be used to gather clinical information in a standardized manner from psoriasis patients participating in clinical and genetics research studies.

PMID:
16713452
[PubMed - indexed for MEDLINE]
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