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Rev Neurol (Paris). 2006 May;162(5):648-50.

[Coeliac disease an spastic paraplegia].

[Article in French]

Author information

  • 1Service de Neurologie, CHU, Monastir, Tunisie.

Abstract

INTRODUCTION:

Celiac disease (CD) is an immune-mediated disease triggered by the ingestion of gluten in genetically susceptible individuals. Neurological manifestations are rare and severe and must be sought systematically.

CLINICAL CASES:

Two non related patients each from a consanguineous marriage developed progressive spastic paraplegia 2 and 8 years respectively after onset of CD. The radiological and biological findings were normal except for the presence of abnormalities related to CD.

CONCLUSION:

The relationship between spastic paraplegia and CD is not well established. Autoimmune, metabolic and genetic mechanisms could be considered but the probability of a fortuitous association should not be ruled out.

PMID:
16710133
[PubMed - indexed for MEDLINE]
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