Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia

Haematologica. 2006 May;91(5 Suppl):ECR09.

Abstract

An 18-month-old girl was diagnosed with pre-pre-B ALL/t(4;11) leukemia, which during the treatment and after matched bone marrow transplantation (BMT), underwent two consecutive switches from lymphoid to myeloid lineage and vice versa. The high expression of HOXA9 and FLT3 genes remaining genotypically stable in a leukemia throughout phenotypic switches, suggests that this leukemia may have originated as a common B/myeloid progenitors.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / analysis*
  • Antigens, Neoplasm / analysis*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • B-Lymphocytes / immunology
  • B-Lymphocytes / pathology*
  • Cell Lineage
  • Chromosomes, Human, Pair 11 / genetics
  • Chromosomes, Human, Pair 11 / ultrastructure
  • Chromosomes, Human, Pair 4 / genetics
  • Chromosomes, Human, Pair 4 / ultrastructure
  • Clone Cells / pathology
  • Combined Modality Therapy
  • Fatal Outcome
  • Female
  • Gene Expression Regulation, Leukemic
  • Gene Rearrangement*
  • Gene Rearrangement, B-Lymphocyte
  • Genes, Immunoglobulin
  • Hematopoietic Stem Cells / immunology
  • Hematopoietic Stem Cells / pathology
  • Histone-Lysine N-Methyltransferase
  • Homeodomain Proteins / genetics
  • Humans
  • Immunophenotyping*
  • Infant
  • Models, Biological
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Neoplasm Proteins / genetics
  • Oncogene Proteins, Fusion / genetics*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / surgery
  • Recurrence
  • Translocation, Genetic
  • fms-Like Tyrosine Kinase 3 / genetics

Substances

  • Antigens, CD
  • Antigens, Neoplasm
  • Homeodomain Proteins
  • KMT2A protein, human
  • MLL-AF4 fusion protein, human
  • Neoplasm Proteins
  • Oncogene Proteins, Fusion
  • homeobox protein HOXA9
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3