Lancet. 1991 Jan 26;337(8735):203-4.

Lipoprotein(a) reduction by N-acetylcysteine.

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Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021-6399.

Abstract

Lipoprotein(a), a complex of low-density lipoprotein linked by disulphide bridges with apo(a), is associated with atherosclerotic disease when present at very high plasma concentrations. In vitro, N-acetylcysteine (NAC) dissociates this complex. In two patients with high Lp(a) levels NAC lowered plasma Lp(a) from 58 to 20 mg/dl and from 59 to 18 mg/dl: reductions of this order have not hitherto been achieved either by drugs or by diet.

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N-acetylcysteine and serum concentrations of lipoprotein(a). [J Intern Med. 1991]
N-acetylcysteine and serum concentrations of lipoprotein(a).
Kroon AA, Demacker PN, Stalenhoef AF. J Intern Med. 1991 Dec; 230(6):519-26.
Defects in the low density lipoprotein receptor gene affect lipoprotein (a) levels: multiplicative interaction of two gene loci associated with premature atherosclerosis. [Proc Natl Acad Sci U S A. 1989]
Defects in the low density lipoprotein receptor gene affect lipoprotein (a) levels: multiplicative interaction of two gene loci associated with premature atherosclerosis.
Utermann G, Hoppichler F, Dieplinger H, Seed M, Thompson G, Boerwinkle E. Proc Natl Acad Sci U S A. 1989 Jun; 86(11):4171-4.
Review Lipoprotein(a) and atherosclerosis. [Ann Intern Med. 1991]
Review Lipoprotein(a) and atherosclerosis.
Scanu AM, Lawn RM, Berg K. Ann Intern Med. 1991 Aug 1; 115(3):209-18.
N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels. [Atherosclerosis. 1996]
N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels.
Wiklund O, Fager G, Andersson A, Lundstam U, Masson P, Hultberg B. Atherosclerosis. 1996 Jan 5; 119(1):99-106.
Review Lp(a) as a marker for coronary heart disease risk. [Clin Cardiol. 1991]
Review Lp(a) as a marker for coronary heart disease risk.
Scanu AM. Clin Cardiol. 1991 Feb; 14(2 Suppl 1):I35-9.

See reviews... See all...

Cited by 2 PubMed Central articles

Review N-acetylcysteine -- passe-partout or much ado about nothing? [Br J Clin Pharmacol. 2006]
Review N-acetylcysteine -- passe-partout or much ado about nothing?
Aitio ML. Br J Clin Pharmacol. 2006 Jan; 61(1):5-15.
Hormonal regulation of serum Lp (a) levels. Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma. [J Clin Invest. 1992]
Hormonal regulation of serum Lp (a) levels. Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma.
Henriksson P, Angelin B, Berglund L. J Clin Invest. 1992 Apr; 89(4):1166-71.

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