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Cancer Res. 2006 May 15;66(10):4987-90.

Regulatory T cells and toll-like receptors in cancer therapy.

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  • 1The 2nd Hospital, Zhejiang University Medical School, Hangzhou, China.


T regulatory (Treg) cells that suppress immune responses may limit the efficiency of cancer immunotherapy. Recent findings indicate that Toll-like receptors (TLR) directly regulate the suppressive activity of Treg cells. Linking TLR signaling to the functional control of Treg cells may offer new opportunities to improve the outcome of cancer immunotherapy by coadminstration of certain TLR ligands.

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