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Cancer Res. 2006 May 15;66(10):4983-6.

Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer.

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  • 1Centre for Immunology, St. Vincent's Hospital and University of New South Wales, Sydney, Australia.


Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.

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