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Med Mal Infect. 2006 Jun;36(6):299-303. Epub 2006 May 15.

[Antibiotic therapy in serious infectious states].

[Article in French]

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  • 1Service de réanimation polyvalente, fondation hôpital Saint-Joseph, 185, rue Raymond-Losserand, 75674 Paris cedex 14, France.


Severe sepsis, which is related to a high mortality rate, requires a very specific antibiotic strategy, which must be adapted to each case. The appropriateness of empiric therapy is based on the delay before administration of the molecule, the bacterial resistance profile, and the kinetic and/or dynamic properties of the available antibiotics.

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