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1: J Bioenerg Biomembr. 2005 Dec;37(6):509-15.Click here to read Links

The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms.

Schölz C, Tampé R.

Institute of Biochemistry, Biocenter, Johann Wolfgang Goethe-University Frankfurt, Marie-Curie-Str. 9, D-60439, Frankfurt a.M., Germany.

The transporter associated with antigen processing (TAP) is a crucial element of the adaptive immune system, which translocates proteasomal degradation products into the endoplasmic reticulum, for transfer of these peptides on major histocompatibility complex (MHC) I molecules within a macromolecular peptide-loading complex. After loading and intracellular transport to the cell surface, these peptide/MHC complexes are monitored by cytotoxic T-lymphocytes. This review summarizes the structural organization and function of the ABC transporter TAP. Furthermore, we discuss human diseases and viral evasion strategies associated with TAP function.

PMID: 16691491 [PubMed - indexed for MEDLINE]