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Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1613-8. Epub 2006 May 11.

Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction.

Author information

  • 1Celera Inc., 1401 Harbor Bay Pkwy, Alameda, California 94502, USA. dov.shiffman@celeradiagnostics.com

Abstract

OBJECTIVE:

Identify gene variants associated with early-onset myocardial infarction (MI).

METHODS AND RESULTS:

We tested 11 647 single-nucleotide polymorphisms (SNPs) for association with early-onset MI in a case-control study (study 1 200 cases, 262 controls). To reduce the number of false positives among the 666 SNPs that were nominally associated with early-onset MI (P<0.05) in study 1, we tested these SNPs in study 2 (434 cases, 504 controls). We found that 8 of the 666 SNPs were associated with early-onset MI in study 2 (P<0.05) and had the same risk alleles as in study 1. These 8 SNPs were then tested for association with early-onset MI in study 3 (187 cases, 434 controls). We found that a VAMP8 variant (P = 0.025; odds ratio [OR], 1.75; CI, 1.17 to 2.62) and an HNRPUL1 variant (P = 0.0043; OR, 1.92; CI, 1.28 to 2.86) were associated with early-onset MI (nominal P<0.05; false discovery rate <10%) and had the same risk alleles in all 3 studies.

CONCLUSIONS:

Variants in 2 genes were associated with early-onset MI: VAMP8, which is involved in platelet degranulation, and HNRPUL1, which encodes a ribonuclear protein. The identification of these variants could improve understanding of disease mechanisms and suggest novel drug targets.

PMID:
16690874
[PubMed - indexed for MEDLINE]
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