Trans R Soc Trop Med Hyg. 2006 Oct;100(10):986-8. Epub 2006 May 11.

Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance.

Berry A, Senescau A, Lelièvre J, Benoit-Vical F, Fabre R, Marchou B, Magnaval JF.

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Department of Parasitology, Rangueil University Hospital, 31059 Toulouse 9, France. berry.a@chu-toulouse.fr

Abstract

The atovaquone resistance of malaria parasites correlates with mutations in the cytochrome b gene. We sequenced the Plasmodium falciparum cytochrome b gene of 135 African isolates. Our data showed a high mutation rate (8.9%); however, the risk of emergence spreading of atovaquone-resistant P. falciparum strains could be limited.

PMID:: 16690094; [PubMed - indexed for MEDLINE]

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