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Int Arch Occup Environ Health. 2006 Nov;80(2):149-53. Epub 2006 May 11.

Cadmium, lead and endometriosis.

Author information

  • 1Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, Universit√© Catholique de Louvain, 30.54 Clos Chapelle aux Champs, 1200, Brussels, Belgium. jean-francois.heilier@toxi.ucl.ac.be

Abstract

OBJECTIVES:

Cadmium (Cd) and lead (Pb) have been demonstrated to exert endocrine disrupting activities. Their possible role in endometriosis, an oestrogen-dependent disease, is unknown.

METHODS:

We compared cadmium urinary excretion (CdU) and blood concentration of cadmium (CdB) and lead (PbB) in 119 patients with peritoneal endometriosis and/or deep endometriotic (adenomyotic) nodules of the rectovaginal septum and 25 controls.

RESULTS:

The mean levels of cadmium in urine and blood did not differ among the groups. Women suffering from endometriotic diseases showed lower levels of PbB than controls.

CONCLUSIONS:

These data do not support a role for cadmium in the onset or the growth of endometriotic diseases but suggest a possible relationship with lead.

[PubMed - indexed for MEDLINE]
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