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J Neurophysiol. 2006 Aug;96(2):721-9. Epub 2006 May 10.

Audio-visual multisensory integration in superior parietal lobule revealed by human intracranial recordings.

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  • 1Cognitive Neurophysiology Lab., Program in Cognitive Neuroscience and Schizophrenia, Nathan S. Kline Inst. for Psychiatric Research, 140 Old Orangeburg Rd., Orangeburg, NY 10962, USA.


Intracranial recordings from three human subjects provide the first direct electrophysiological evidence for audio-visual multisensory processing in the human superior parietal lobule (SPL). Auditory and visual sensory inputs project to the same highly localized region of the parietal cortex with auditory inputs arriving considerably earlier (30 ms) than visual inputs (75 ms). Multisensory integration processes in this region were assessed by comparing the response to simultaneous audio-visual stimulation with the algebraic sum of responses to the constituent auditory and visual unisensory stimulus conditions. Significant integration effects were seen with almost identical morphology across the three subjects, beginning between 120 and 160 ms. These results are discussed in the context of the role of SPL in supramodal spatial attention and sensory-motor transformations.

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