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Curr Opin Genet Dev. 1991 Oct;1(3):391-6.

Pheromone signaling pathways in yeast.

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  • Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037.


The discovery that the transducing G protein of the Saccharomyces cerevisiae mating pheromone response figures centrally in signal adaptation was the focus of considerable excitement in the past year. Not only does activated G alpha in this system stimulate an adaptive signal but G beta undergoes a desensitizing phosphorylation in response to pheromone signaling.

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