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1: Nat Clin Pract Oncol. 2006 May;3(5):281-4; quiz 285.Click here to read Links

Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum.

Goswami RS, Minoo P, Baker K, Chong G, Foulkes WD, Jass JR.

Anatomic Pathology, McGill University, Montreal, QC, Canada.

BACKGROUND: A 64-year-old woman presented to the emergency room with a 3-month history of intermittent abdominal cramps, accompanied by nausea, vomiting, anorexia, and decreased bowel movements consistent with a partial intestinal obstruction. She had a 12-year history of peptic ulcers, which had been treated with histamine-2 blockers. INVESTIGATIONS: Physical examination, abdominal X-ray, abdominal CT scan, colonoscopy and assessment of gastrin levels. DIAGNOSIS: Duodenal neuroendocrine neoplasm showing gastrin expression and stage III (T3N2M0), poorly differentiated adenocarcinoma of the cecum arising from hyperplastic polyposis. MANAGEMENT: Right-sided hemicolectomy with ileocolonic anastomosis, duodenal resection, leucovorin and 5-fluorouracil chemotherapy, annual colonoscopic surveillance, and polypectomy.

PMID: 16683006 [PubMed - indexed for MEDLINE]

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