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Eukaryot Cell. 2006 May;5(5):871-5.

Stress by heat shock induces massive down regulation of genes and allows differential allelic expression of the Gal/GalNAc lectin in Entamoeba histolytica.

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  • 1Unité Biologie Cellulaire du Parasitisme, INSERM 786, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France.

Abstract

Gene expression analysis by microarray assay revealed that when exposed to stress, Entamoeba histolytica exhibits a specific heat shock response, together with a dramatic overall reduction in gene transcription as well as differential allelic expression of key genes participating in virulence, such as the galactose/N-acetylgalactosamine (Gal/GalNAc) lectin.

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