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Trends Genet. 1991 Nov-Dec;7(11-12):393-8.

Signal transduction in yeast mating: receptors, transcription factors, and the kinase connection.

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  • Institute of Molecular Biology, University of Oregon, Eugene 97403.

Abstract

In the yeast Saccharomyces cerevisiae, peptide mating pheromones activate a signal transduction pathway that leads to cellular differentiation and cell division cycle arrest. It is now possible to trace the major events of this pathway. binding of pheromone to G-protein-coupled receptors activates a cascade of serine/threonine protein kinases that ultimately phosphorylate and increase the activity of an identified transcription factor.

PMID:
1668192
[PubMed - indexed for MEDLINE]
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