Curr Opin Neurobiol. 2006 Jun;16(3):275-80. Epub 2006 May 5.

Learning from stargazin: the mouse, the phenotype and the unexpected.

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Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave, Chicago, IL 60611, USA. p-osten@northwestern.edu

Abstract

The stargazin gene (also referred to as Cacng2) has been identified by forward genetics in a spontaneous mouse mutant with ataxic gait, upward head-elevating movements (hence the name stargazer for the mouse) and episodes of spike-wave discharges. Stargazin is related to the gamma-1 subunit of skeletal muscle voltage-dependent calcium channel (VDCC), and a deficit in its role as auxiliary VDCC subunit was proposed to underlie the epileptic phenotype of the mouse; yet, a conclusive demonstration of stargazin function in VDCC regulation is still lacking. In contrast, stargazin and its three closely related isoforms gamma-3, gamma-4 and gamma-8 were shown to function as auxiliary subunits for a very different ion channel - the AMPA-type glutamate receptor - prominently regulating early intracellular transport, synaptic targeting and anchoring, and ion channel functions of this major excitatory receptor in the brain.

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Learning from stargazin: the mouse, the phenotype and the unexpected.
Learning from stargazin: the mouse, the phenotype and the unexpected.
Curr Opin Neurobiol. 2006 Jun ;16(3):275-80. Epub 2006 May 5 .

PubMed
Phosphorylation of stargazin by protein kinase A regulates its interaction with ...
Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95.
J Biol Chem. 2002 Apr 5 ;277(14):12359-63. Epub 2002 Jan 22 .

PubMed
Stargazin modulates AMPA receptor gating and trafficking by distinct domains.
Stargazin modulates AMPA receptor gating and trafficking by distinct domains.
Nature. 2005 Jun 23 ;435(7045):1052-8. Epub 2005 Apr 27 .

PubMed
Stargazin reduces desensitization and slows deactivation of the AMPA-type glutam...
Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors.
J Neurosci. 2005 Mar 9 ;25(10):2682-6.

PubMed
Stargazin controls the pharmacology of AMPA receptor potentiators.
Stargazin controls the pharmacology of AMPA receptor potentiators.
Proc Natl Acad Sci U S A. 2006 Jun 27 ;103(26):10064-7. Epub 2006 Jun 19 .

PubMed

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Learning from stargazin: the mouse, the phenotype and the unexpected.

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