Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2006 Jun;22(6):297-301. Epub 2006 May 4.

Dissecting the mammalian genome--new insights into chromosomal evolution.

Author information

  • 1Evolutionary Genomics Group, Department of Botany and Zoology, University of Stellenbosch, South Africa. tjr@sun.ac.za


A recent study aligning genomic data from eight mammalian species has provided new and detailed information on the architecture of chromosomes that are thought to comprise the karyotype of the boreoeutherian ancestor. The analyses suggest that evolutionary breakpoints are clustering in "hotspots", that these regions are enriched for centromeres and that the more commonly occurring human cancer-associated breakpoints tend to co-localize with evolutionary breakpoints.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk