FEBS Lett. 2006 May 22;580(12):2811-20. Epub 2006 Apr 21.

The logic of TGFbeta signaling.

Source

Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, P.O. Box 116, 1275 York Avenue, New York, NY 10021, USA. j-massague@ski.mskcc.org

Abstract

The identification of the TGFbeta cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie critical cell fate and developmental decisions. The deconstruction of one of these responses - the cell cycle arrest response - into its elemental molecular parts has shed light into the mechanisms used by tumors to evade surveillance and cause metastasis.

PMID:: 16678165; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Transforming Growth Factor beta

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Review Smad transcription factors. [Genes Dev. 2005]
Review Smad transcription factors.
Massagué J, Seoane J, Wotton D. Genes Dev. 2005 Dec 1; 19(23):2783-810.
Review The regulation of TGFbeta signal transduction. [Development. 2009]
Review The regulation of TGFbeta signal transduction.
Moustakas A, Heldin CH. Development. 2009 Nov; 136(22):3699-714.
Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity. [Stem Cells Dev. 2008]
Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity.
Greber B, Lehrach H, Adjaye J. Stem Cells Dev. 2008 Dec; 17(6):1065-77.
Review [TGFbeta, activin and SMAD signalling in thyroid cancer]. [Arq Bras Endocrinol Metabol. 2007]
Review [TGFbeta, activin and SMAD signalling in thyroid cancer].
Kimura ET, Matsuo SE, Ricarte-Filho JC. Arq Bras Endocrinol Metabol. 2007 Jul; 51(5):683-9.
Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. [J Immunol. 2008]
Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506.
Akool el-S, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, Pfeilschifter J, Eberhardt W. J Immunol. 2008 Aug 15; 181(4):2831-45.

See reviews... See all...

Cited by 95 PubMed Central articles

The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina. [Development. 2011]
The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina.
Hirota S, Liu Q, Lee HS, Hossain MG, Lacy-Hulbert A, McCarty JH. Development. 2011 Dec; 138(23):5157-66.
The Local Control of the Pituitary by Activin Signaling and Modulation. [Open Neuroendocrinol J. 2011]
The Local Control of the Pituitary by Activin Signaling and Modulation.
Bilezikjian LM, Vale WW. Open Neuroendocrinol J. 2011 Jan 1; 4:90-101.
Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice. [J Clin Invest. 2011]
Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice.
Hahn JN, Falck VG, Jirik FR. J Clin Invest. 2011 Oct; 121(10):4030-42. Epub 2011 Sep 1.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

The logic of TGFbeta signaling.
The logic of TGFbeta signaling.
FEBS Lett. 2006 May 22 ;580(12):2811-20. Epub 2006 Apr 21 .

PubMed
Association of autistic spectrum disorder and the measles, mumps, and rubella va...
Association of autistic spectrum disorder and the measles, mumps, and rubella vaccine: a systematic review of current epidemiological evidence.
Arch Pediatr Adolesc Med. 2003 Jul ;157(7):628-34.

PubMed
Preventing vascular access dysfunction: which policy to follow.
Preventing vascular access dysfunction: which policy to follow.
Blood Purif. 2002 ;20(1):26-35.

PubMed
Arguments in favour of a homologous concept for hemodialysis access procedures. ...
Arguments in favour of a homologous concept for hemodialysis access procedures. Feasibility and results.
Eur J Vasc Endovasc Surg. 2003 Jul ;26(1):96-9.

PubMed
Osteo-nevus of Nanta (osseous metaplasia in a benign intradermal melanocytic nev...
Osteo-nevus of Nanta (osseous metaplasia in a benign intradermal melanocytic nevus): an uncommon phenomenon.
Dermatol Online J. 2007 Oct 13 ;13(4):16.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: