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1: Cancer Lett. 2007 Feb 8;246(1-2):324-30. Epub 2006 May 4.Click here to read Links

Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer.

Costa S, Pinto D, Pereira D, Vasconcelos A, Afonso-Lopes C, Osório T, Lopes C, Medeiros R.

ICVS, Life and Health Sciences Research Institute, Health Science School, Minho University, Braga, Portugal. sandracostas@portugalmail.com

The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case-control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (OR=2.46 95% CI 1.20-5.06; P=0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (OR=3.40 95% CI 1.61-7.15; P=0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer.

PMID: 16677755 [PubMed - indexed for MEDLINE]