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Genome Biol. 2006;7(4):213. Epub 2006 Apr 28.

TANGOing along the protein secretion pathway.

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  • 1University Medical Center Utrecht, The Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, Heidelberglaan 100, 3584CX Utrecht, The Netherlands. C.Rabouille@lab.azu.nl

Abstract

Although the organization and functions of the constitutive secretory pathway have been intensively studied for decades, a recent genome-wide RNAi screen in Drosophila cells has identified about 100 genes encoding novel so-called TANGO proteins (for transport and Golgi organization) that may be direct regulators of various aspects of protein exocytosis or secretion.

PMID:
16677429
[PubMed - indexed for MEDLINE]
PMCID:
PMC1557995
Free PMC Article

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