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Science. 2006 May 5;312(5774):758-62.

Conjunctive representation of position, direction, and velocity in entorhinal cortex.

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  • 1Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway.

Abstract

Grid cells in the medial entorhinal cortex (MEC) are part of an environment-independent spatial coordinate system. To determine how information about location, direction, and distance is integrated in the grid-cell network, we recorded from each principal cell layer of MEC in rats that explored two-dimensional environments. Whereas layer II was predominated by grid cells, grid cells colocalized with head-direction cells and conjunctive grid x head-direction cells in the deeper layers. All cell types were modulated by running speed. The conjunction of positional, directional, and translational information in a single MEC cell type may enable grid coordinates to be updated during self-motion-based navigation.

PMID:
16675704
[PubMed - indexed for MEDLINE]
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