Science. 2006 May 5;312(5774):738-41.

B cell ligand discrimination through a spreading and contraction response.

Fleire SJ, Goldman JP, Carrasco YR, Weber M, Bray D, Batista FD.

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Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.

Abstract

B cells recognize foreign antigens by virtue of cell surface immunoglobulin receptors and are most effectively activated by membrane-bound ligands. Here, we show that in the early stages of this process, B cells exhibit a two-phase response in which they first spread over the antigen-bearing membrane and then contract, thereby collecting bound antigen into a central aggregate. The extent of this response, which is both signaling- and actin-dependent, determines the quantity of antigen accumulated and hence the degree of B cell activation. Brownian dynamic simulations reproduce essential features of the antigen collection process and suggest a possible basis for affinity discrimination. We propose that dynamic spreading is an important step of the immune response.

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Science. 2006 May 5;312(5774):709-10.

PMID:: 16675699; [PubMed - indexed for MEDLINE]

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