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Neuron. 2006 May 4;50(3):348-50.

Keeping time without a clock.

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  • 1Biology Department, New York University, 100 Washington Square East, New York, New York 10003, USA.

Abstract

The accepted dogma in circadian biology is that the transcription factor CLOCK lies at the heart of the molecular clock that drives behavioral and molecular rhythms. In this issue of Neuron, the generation of CLOCK-deficient mice with only subtle clock defects by DeBruyne et al. shakes up this view of the mammalian clock.

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PMID:
16675389
[PubMed - indexed for MEDLINE]
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