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J Bacteriol. 2006 May;188(10):3716-20.

Evidence that Clostridium difficile TcdC is a membrane-associated protein.

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  • 1Department of Microbiology and Immunology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, 79430, USA.


Clostridium difficile produces two toxins, A and B, which act together to cause pseudomembraneous colitis. The genes encoding these toxins, tcdA and tcdB, are part of the pathogenicity locus, which also includes tcdC, a putative negative regulator of the toxin genes. In this study, we demonstrate that TcdC is a membrane-associated protein in C. difficile.

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