Format

Send to:

Choose Destination
See comment in PubMed Commons below
Development. 2006 Jun;133(11):2095-104. Epub 2006 May 3.

The left-right axis in the mouse: from origin to morphology.

Author information

  • 1Developmental Genetics Group, Graduate School for Frontier Biosciences, Osaka University, Japan Science and Technology Corporation.

Abstract

The past decade or so has seen rapid progress in our understanding of how left-right (LR) asymmetry is generated in vertebrate embryos. However, many important questions about this process remain unanswered. Although a leftward flow of extra-embryonic fluid in the node cavity (nodal flow) is likely to be the symmetry-breaking event, at least in the mouse embryo, it is not yet known how this flow functions or how the asymmetric signal generated in the node is transferred to the lateral plate. The final step in left-right patterning - translation of the asymmetric signal into morphology - is also little understood.

PMID:
16672339
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk