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Org Lett. 2006 May 11;8(10):1963-6.

Chiral silanes via asymmetric hydrosilylation with catalytic CuH.

Author information

  • 1Department of Chemistry and Biochemistry, University of California, Santa Barbara, 93106, USA. lipshutz@chem.ucsb.edu

Abstract

[reaction: see text] CuH-catalyzed asymmetric conjugate reduction of beta-silyl-alpha,beta-unsaturated esters has been developed. Using PMHS as a stoichiometric source of hydride and in situ generated CuH ligated by Solvias' JOSIPHOS analogue PPF-P(t-Bu)(2) leads to highly enantioselective 1,4-reductions.

PMID:
16671757
[PubMed]
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