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Eur J Clin Nutr. 2006 Oct;60(10):1201-6. Epub 2006 May 3.

Effect of a novel dietary supplement on skin aging in post-menopausal women.

Author information

  • 1Department of Dermatology, University of Copenhagen, Copenhagen, Denmark. asj@ferrosan.com



The aim of the present study was to quantify the effects on skin in post-menopausal women of a novel dietary supplement (Imedeen Prime Renewal) that contained soy extract, fish protein polysaccharides, extracts from white tea, grape seed and tomato, vitamins C and E as well as zinc and chamomile extract.


The study was a 6-month double blind, placebo controlled, randomized study on healthy post-menopausal females.


The study was performed at a commercial Contract Research Organisation (TJ Stephens & Associates Inc., TX, USA).


Two tablets of Imedeen Prime Renewal or placebo were given twice daily for 6 months.


Thirty-eight (active group) and 42 (placebo group) subjects completed the study out of 100.


Clinical grading showed that the active group had a significantly greater improvement (P < 0.05) compared to placebo for the face after 6 months treatment for: forehead, periocular and perioral wrinkles, mottled pigmentation, laxity, sagging, under eye dark circles and overall apperance; skin on the d├ęcolletage after 2, 3 and 6 months treatment and skin on the hand after 3 and 6 months treatment. Photo evaluation showed that the active group had a significantly greater improvement (P < 0.05) on the face after 3 and 6 months for several parameters. Ultrasound measurements showed that the active group had a significantly greater improvement (P < 0.0001) for density measurements after 6 months treatment.


In summary, this novel dietary supplement, Imedeen Prime Renewal, provides improved condition, structure and firmness of the skin in post-menopausal women after 6 months.

[PubMed - indexed for MEDLINE]
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