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J Am Chem Soc. 2006 May 10;128(18):5986-7.

Cellular uptake of PNA--terpyridine conjugates and its enhancement by Zn2+ ions.

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  • 1European Molecular Biology Laboratory (EMBL) Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Abstract

Conjugation of usually impermeable peptide nucleic acids (PNA) to the chelator 2,2':6',2' '-terpyridine strongly promotes cellular and nuclear uptake by cultured HeLa cells. Cellular accumulation is further enhanced in the presence of extracellular Zn2+.

PMID:
16669638
[PubMed - indexed for MEDLINE]
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