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Pediatrics. 2006 May;117(5):e821-6.

The safety of trivalent influenza vaccine among healthy children 6 to 24 months of age.

Author information

  • 1HealthPartners Research Foundation, Minneapolis, Minnesota 55440-1524, USA. michael.j.goodman@healthpartners.com

Erratum in

  • Pediatrics. 2006 Sep;118(3):1324.

Abstract

OBJECTIVE:

The objective of this study was to assess the safety of routine trivalent influenza vaccine (TIV) administration among healthy children 6 through 23 months of age, after the Advisory Committee on Immunization Practices recommendation.

METHODS:

The study was a retrospective case-control study of children receiving TIV in the first 2 seasons after the Advisory Committee on Immunization Practices recommendation. We assessed outcomes in the 42 days after vaccination in a population of 13,383 children. Each case subject was matched, according to age and gender, with 3 control subjects. Hazard ratios were calculated with conditional logistic regression analysis.

RESULTS:

We found no statistically significantly elevated hazard ratios for the first TIV dose. An elevated risk of pharyngitis was found for children receiving a second TIV dose. No elevated risk of seizure was found.

CONCLUSION:

These results, for a population of healthy children, showed no medically significant adverse events related to TIV among children 6 to 23 months of age.

PMID:
16651286
[PubMed - indexed for MEDLINE]
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